Trinh Phan Canh
Group: Karl Kuchler
Fungal infections are under-recognized hidden killers in infectious diseases, since they claim about 1.5 million human lives per year, with Candida species representing the most prevalent fungal pathogens. Candida auris is a newly emerging fungal pathogen, showing untreatable clinical resistance to all known antifungal drugs. This project applies an integrated poly-omics strategy to discover pathogenesis mechanisms of C. auris. We hypothesize that morphogenesis and metabolic genes control drug resistance and virulence traits of C. auris that promote host colonization and immune evasion. Based on comparative data between different clinical multidrug-resistant C. auris strains, we identify inter-twined mechanisms of morphogenesis, adhesion as well as invasion using in vivo mouse and ex vivo human skin infection models.