Group: Michael Jantsch
Adenosine to inosine deamination by ADARs is the most abundant type of RNA editing in metazoans. A-to-I RNA editing has been shown to play an essential role in mammalian embryonic development and tissue homeostasis. ADAR-mediated editing of endogenous dsRNAs is critical to distinguish self- from non self-RNAs. Further, A to I RNA editing recodes proteins essential for tissue homeostasis. The aims of the project are, 1) to identifying the endogenous RNAs that activate antiviral responses in the absence of A to I editing , and 2) to determine the impact of protein recoding on tissue homeostasis and microbiome dysbiosis in intestinal inflammation.